Research of Oscillating Magnetic Field TherapyU.S. Patent 4,665,898: Malignancy Treatment
FDA report: Kinetics of Microbial Inactivation
U.S. Patent 4,524,079: Deactivation of Microorganisms by an Oscillating
Magnetic Field
U.S. Patent 4,665,898
Inventor: Jonathan L. Costa, Gunter A. Hofmann
Date: May 19, 1987
Malignancy Treatment
Abstract
A body part of an animal afflicted with malignant cells is disposed within a
magnetic coil and subjected to a plurality of magnetic field pulses, the pulses
having intensities of between about l and about 100 Tesla and characteristic
frequencies of between about 5 and about 100 kHz. The pulses magnetic field
selectively inactivates and/or destroys malignant cells with relatively little
damage to normal tissue.
Summary of the Invention
... Herein, it is discovered that high intensity magnetic fields applied in
short pulses with moderate frequencies, can be used to selectively destroy or
otherwise inactivate malignant cells within tissue of a living animal. Selective
inactivation of malignant cells within animal tissue subjected to a pulsed
magnetic field is accomplished without noticeable deterioration of gross
characteristics of normal tissue.
Detailed Description of a Preferred Embodiment
It is found that subjecting body parts containing cancerous tissue to a
plurality of magnetic field pulses, with characteristic frequencies above about
5 kHz and intensities above about 1 Tesla, will either arrest the growth of
tumors or progressively reduce the number of cancerous cells, resulting in
remission of tumors... The magnetic field in the coil is produced upon discharge
of a bank of capacitors. The capacitor bank is charged from a source, and when a
switch is closed... an oscillating current can be generated between the plates
of the capacitors. The oscillating current, in turn, generates a pulsed magnetic
field which is concentrated within the region bounded by the coil... Immediately
subsequent to closing the switch, an intense magnetic field is produced by
current flowing in one direction. As the current changes direction, the magnetic
field changes polarity... The oscillating current and, hence, the oscillating
magnetic field rapidly decreases after about ten oscillations dropping to a few
percent of the original magnetic field strength. Herein, magnetic field
intensities refer to the intensities of the initial peaks... The method is
applicable to practically any type of tissue and is believed applicable for
treatment of most types of malignancies... In each session, an animal is exposed
to at least 1 and up to 1000 magnetic pulses. Generally a living animal would be
subjected to at least ten pulses at each therapy session and up to one hundred
pulses. An animal will be subjected to additional sessions until tumor remission
is achieved... Malignant cells are more susceptible to destruction and/or
inactivation by a pulsed intense electromagnetic field because the field may
create eddy currents that are unique to the tumor. These localized eddy currents
may cause effects that are deleterious to the viability and/or reproductive
capability of the tumor cells. Alternatively, there may be macromolecules unique
to malignant cells which are especially magnetically susceptible... Furthermore,
treatment with a pulsed magnetic field does far less damage to the natural
immune system than does radiation treatment or chemotherapy. Frequently, a
patient who is treated extensively with ionizing radiation and/or with
chemotherapy will experience an almost complete breakdown of the immune system.
Subsequent to treatment, the immune system may take up to a year to recover,
particularly with respect to immunity to viral infections. As a result, even if
a patient is cured of the malignancy by radiation and/or chemotherapy, he is
subject to debilitating disease or even death by infections to which his body
would ordinarily have built up immunity. With the magnetic treatment described
herein, there has been no evidence of major immune system beak-down.
TABLE 2
Evaluation of the Growth of Rat Mammary Tumors Following Multiple Exposures to a
Rapidly Varying Magnetic Field
Partial or Complete Response
Total
Total Tumors
Tumor
No. of Interruption
Responding
Type Tesla/kHz Tumors of Growth Shrinkage in percent
DMBA 5T / 8kHz
8
2
6
100%
primary
NMU 5T / 8kHz
10
1
9
100%
primary
It can be seen from the above table that the
method of the present invention is useful for treating a variety of
malignancies, although the response varies according to the type of tumor.
Accordingly, the method has general applicability to malignancy treatment.
Example 3
Twelve rats having primary DMBA-induced mammary carcinomas were treated daily
with a conventional Magneform machine. A primary mammary gland carcinoma induced
by a carcinogen, such as DMBA or NMU, is highly virulent, as outlined in
substantial detail in P. M. Guillino, et al., Journal of the National Cancer
Institute, Vol. 54, no. 2, February 1974. It is common for such a tumor in a rat
to increase in size by about 10 to 30 fold in about 30 days, and if left
untreated almost invariably will ulcerate within about 45 days. Ten of the rats
are treated daily with 20 pulses at 5 Tesla and 8 KHz. Their tumor volumes on
the 1st and 30th days are listed in with table 3 below:
TABLE 3
Test Tumor volume (cm3) Rat Day 1 Day 30 1. 1.60 1.95 2. 1.20 3.65 3. 2.10 1.20 4. 1.40 3.81 5. .90 .42 6. 3.00 3.81 7. .38 .45 8. 2.10 8.18 9. 6.79 8.88 10. 1.10 .85 It can be seen from the above table that after
thirty days the tumors were either diminished in size, stabilized, or at least
controlled relative to untreated tumors... The remaining two rats were treated
in an identical manner but at 1/4th the field intensity, i.e., 1.2 Tesla, 8 kHz,
20 pulses. One of these died on day 58 while the tumor size of the other had
decreased in size from 1.6 cm3 on day 1 to 1.4 cm3 on day
62. The rats generally appeared to exhibit normal behavior and appetite and did
not appear to lose weight. The fact that the rats did not die of infections
suggested that the immune systems functioned normally.
Michael's Notes on Patent 4,665,898
This device produces the same type of oscillating magnetic field as does my OMF
Generator. The basic design of mine is the same, with a capacitor (charged
with high voltage) connected in parallel with a coil to produce a decaying oscillating
magnetic field. This patents device varies from mine in application only by the
test subject being placed inside the coil, whereas mine was used so that the
coil rests on the test subject which is effected by the lines of magnetic force
emanating from the coil. Field force becomes less and less
with more distance from the center of the coil as is indicated by the field
force lines separating more. The results of test example 1 is a reduction of
live cancer cells (in test tube) of 32% of undifferentiated carcinoma and 29% of
embryonic carcinoma after 18 days. This was after 8 pulses of oscillating
magnetic field of 5 Tesla at 8000 hertz on day 1. The results of test example 2 is
75% and 90% of treated rat mammary tumors (6 of 8 DMBA primary tumors, and 9 of
10 NMU primary tumors) shrunken after 20 pulses daily of OMF at 5 Tesla and 8000 hertz for 6 days. The results of test example 3 is an average 86% reduction of
tumor size after 30 days (compared to a typical 20 times tumor growth after 30
days). Treatment was with 20 pulses OMF of 5 Tesla at 8000 hertz daily for 30 days.
Tumors were induced by injection of the DMBA chemical. The table below has
columns for the typical 20x size after 30 days and the percent reduction of the
treated tumors compared to the 20x size. It also shows the equally positive
lower intensity (1.2 Tesla) test results on one tumor with a resultant 96%
reduction.
TABLE 3
Tumor Volume (cm3) .
typical size after 30 days percent
Rat Day 1 Day 30 if left untreated (x20 size) reduction
l. 1.60 1.95
32.
94%
2. 1.20 3.65
24.
85%
3. 2.10 l.20
42.
97%
4. 1.40 3.81
28.
86%
5. .90 .42
18.
98%
6. 3.00 3.81
60.
94%
7. .38 .45
7.6
94%
8. 2.10 8.18
42.
8l%
9. 6.79 8.88
13.6
35%
l0. 1.1 .85
22. 96%
average 86%
treatment with 20 pulses of 1.2 Tesla at 8 kHz for 30 days
11. l.6 1.40
32.
96%
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U.S. Food and Drug Administration
Center for Food Safety and Applied Nutrition
June 2, 2000
Kinetics of Microbial Inactivation for Alternative Food Processing Technologies Oscillating Magnetic Fields
Scope of Deliverables
This section reports the effects of magnetic fields on microbial populations.
1. Definition, Description and Application
Static (SMF) and oscillating (OMF) magnetic fields have been explored
for their potential as microbial inactivation methods... an OMF is
applied in the form of constant amplitude or decaying amplitude
sinusoidal waves. OMF applied in the form of pulses reverse the charge
for each pulse, and the intensity of each pulse decreases with time to
about 10% of the initial intensity (Pothakamury and others 1993).
Preservation of foods with OMF involves sealing food in a plastic bag
and subjecting it to 1 to 100 pulses in an OMF with a frequency between
5 to 500 kHz at temperatures in the range of 0 to 50 degrees Celsius
for a total exposure time ranging from 25 to 100 milliseconds. OMF of
intensity of 5 to 50 tesla (T) and frequency of 5 to 500 kHz (5000 -
500,000) was applied and reduced the number of microorganisms by at
least 2-log cycles (1/100th ). OMF of this intensity can be generated
using: (1) superconducting coils; (2) coils which produce DC fields or
(3) coils energized by the discharge of energy stored in a capacitor (Gersdof and others 1983). Inhibition or stimulation of the growth of
microorganisms exposed to magnetic fields may be a result of the
magnetic fields themselves or the induced electric fields. The latter
is measured in terms of induced electric field strength and induced
current density.
2. Inactivation of Microorganisms
Table 1. Effect of magnetic fields in microorganisms.
type of
field frequency magnetic micro-
strength of pulse field organism Effect
12 tesla 6000 OMF
Streptococcus Cell population reduced
(1
pulse) Themophilus from 25,000 cells/ml to
Moore (1985)
in milk 970
7.5 tesla 8500 OMF
Mold spores Population reduced from
(1
pulse) 3,000 spores/ml to 1 Hofmann (1985)
Hofmann
(1985) reported on the inactivation of microorganisms with OMF in milk,
yogurt, orange juice and bread roll dough. According to Hofmann (1985)
only 1 pulse of OMF was adequate to reduce the bacterial population to
between 1% and .1%.
References
Hofmann G.A. 1985. Deactivation of microorganisms by an oscillating magnetic field.
U.S. Patent 4,524,079.
Moore, R.L. 1979. Biological effects of magnetic fields Studies with microorganisms. Can. J. Microbiol., 25:1145-1151
Gersdorf, R., deBoer, F.R., Wolfrat, J.C., Muller, F.A.,
Roeland, L. W. 1983. The high magnetic facility of the University of
Amsterdam, high field magnetism. Proceedings International Symposium on
High Field Magnetism. Osaka, Japan. 277-287
Pothkamury, U.R., Barbosa-Canovas, G.V., and Swanson, B.G.
(1993). Magnetic-field inactivation of microorganisms and generation of
biological changes. Food Technol. 47(12):8593
Michael's Notes:
This papers test results revealing
effectiveness against bacteria and fungi/mold, and patent 4,524,079, is
what inspired me to create my own version of the mentioned device. The OMF
Generator I sell
is an oscillating magnetic field generator
(with an OMF of decaying amplitude as Hofmann and Moore used) with a
magnetic field strength of around .6 Tesla and a frequency of around 10,000 cycles per second
(10
KHz). Its electromagnetic coil is energized
by the discharge of energy stored in a capacitor. The experiences of
myself and others with the OMF Generator are in agreement with the
scientific test results of Moore and Hofmann in that it appeared effective
against bacteria and mold (fungus) although our test medium was human
tissue instead of food. Their test results showed a 96% reduction of
streptococcus bacteria (at 6kHz/12T) and a 99.9% reduction of mold
spores (at 8.5kHz/7.5T).
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U.S. Patent 4,524,079
Inventor: Gunter A. Hofmann
Date: June 18, 1985
Deactivation of Microorganisms by an Oscillating Magnetic Field
Abstract
Material... such as food products... is disposed within a magnetic coil and
subjected to one or more pulses of an oscillating magnetic field having an
intensity of between 2 and about 100 Tesla and a frequency of between 5 and
about 500 kHz. A single pulse of the magnetic field generally decreases the
microorganism population by at least about two orders of magnitude. [1/100th]
Detailed Description of a Preferred Embodiment
The magnetic field in the coil is produced upon discharge of a capacitor. The
capacitor is charged from a source, and when a switch is closed... an
oscillating current is generated between the plates of the capacitor. The
oscillating current in turn generates an oscillating magnetic field which is
concentrated within the region bounded by the coil... Immediately subsequent to
closing the switch, an intense magnetic field is produced by current flowing in
one direction. As the current changes direction, the magnetic field changes
polarity. The oscillating current and, hence, the oscillating magnetic field
rapidly deteriorates, with the field intensity after about ten oscillations
dropping to a few percent of the original intensity. Herein, magnetic field
intensities refer to the intensity of the initial peaks... Herein pulse duration
is considered to be 10 oscillations, after which the substantially decayed field
has a negligible effect.
Example 1
A sample of pasteurized milk is... inoculated with Streptococcus thermophilus at
a concentration of 25,000 bacterium/cm3... The milk is subjected to 1
pulse of a 12 Tesla, 6kHz, oscillating magnetic field... An aliquot of the milk
is plated on a standard plate. The colony count of the plate shows a
concentration of about 970 Streptococcus thermophilus per cm3.
Example 2
350g of plain 4% fat yogurt is opened, inoculated with Saccharomyces at a
concentration of 3,500 bacteria/cm3 and stirred thoroughly. The
container full of inoculated yogurt is placed centrally within the coil
described above and subjected to 10 pulses of a 40 Tesla, 416 kHz oscillating
magnetic field. A sample of the yogurt is plated on standard plates, and a count
of the cultures reveals a concentration of only about 25 Saccharomyces bacteria
per cm3 of yogurt.
Example 4
A prepackaged dough product... is thoroughly mixed with mold spores to give a
concentration of 3000 spores/cm3. The chopped rolls... was centered
in the above-described coil where it was subjected to l pulse of 7.5 Tesla, 8.5
kHz, oscillating magnetic field. A sample of the chopped rolls is plated on
standard plates, and a culture count shows a mold spore concentration of only
about 1 spore per cm3.
Michael's Notes on Patent 4,524,079
This device produces the same type of oscillating magnetic field as does my OMF
Generator. The basic design of mine is the same, with a capacitor (charged with
high voltage) connected in parallel with a coil to produce a decaying oscillating magnetic field.
This patents device varies from mine in application only by the test product
being placed inside the coil, whereas mine is used so that the coil rests on the
test subject which is effected by the lines of magnetic force emanating from the
coil. Field force becomes less and less with more distance from the center of
the coil. The patents results of test example 1 is a 96% reduction of bacteria
(from 25,000 to 970). The patents results of test example 2 is a 99.3% reduction
of bacteria (from 3,500 to 25). The results of test example 4 is a 99.9%
reduction of fungi spores (from 3000 to l ). |
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